Consequences of COVID-19 lockdown on the misuse and marketing of addictive substances and new psychoactive substances

Since the first outbreak of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) in China in December 2019, the infection has rapidly spread all over the world. This new virus has caused many cases of Coronavirus disease 2019 (COVID-19), a potentially fatal respiratory syndrome (1). Due to its global diffusion, the World Health Organization rapidly issued an international warning and declared a worldwide pandemic in March 2020. Currently, most countries are experiencing COVID-19 outbreaks with new infections and fatalities every day and all over the world (2). Due to the mode of transmission of the virus via droplets or direct contact, governments were compelled to adopt restrictive strategies to contain the pandemic and preserve the public health (2, 3). These interventions include limited international mobility, temporary closure of non-essential businesses and more stringent measures like social distancing or complete isolation for prolonged periods. Therefore, this unprecedented crisis has seriously impacted the global economy and people's daily life. The market of addictive substances has been impacted from the production to the distribution, modifying consumption patterns. An increased consumption of cannabis products and benzodiazepines was reported due to the general feeling of stress caused by the pandemic and associated restrictions, while a decrease in the demand of stimulants was observed due to the inaccessibility of usual recreational settings (4). Moreover, drug misuse may have shifted toward alternative substances and home-made New Psychoactive Substances (NPS) (5–7), which consist of molecules, like pharmaceutical drug analogs, research chemicals and prescription drugs eliciting the psychoactive effects of common illicit addictive drugs or prescription pharmaceuticals (8, 9). The current situation is complex due to the heterogeneity of policies applied in diverse countries and the drugs involved. In this concern, the drug market is constantly monitored by international agencies, such as the United Nation Office on Drug and Crime (UNODC), the European Monitoring Centre on Drugs and Drug Addiction (EMCDDA) and Europol, which collaborate to form a crucial network to prevent the emergence of new dangerous trends. In this article, the authors critically discuss the most recent data on the impact of COVID-19 on the illicit trafficking of substances and the possible developments of NPS trends in the near future. The authors also draw the attention on the essential role of international networking against drug misuse, especially in times of global crisis.